Thursday, May 1, 2014

IVF #4 Results

13 eggs retrieved

Day 1: April 30, 2014: 10 were mature and 9 fertilized!!! That's my best response yet!

Day 2: May 1, 2014: All 9 still growing. 8 are 4 cell (right where they're supposed to be) and 1 is a 3 cell. We decided we're going to PGS them and include the 7 frozen since we're going to do it anyways. I hope this is the right decision.

Day 3: May 2, 2014: Feeling more discouraged today. :( They are supposed to be 8 cell today. 6 are 8 cell, BUT 3 of those are experiencing 10-15% fragmentation. One is a perfect 6 cell. (This doesn't worry me. I've had 3 6 cellers on day 3 before and they all made it to blast.) The other 2 are a 4 cell and a 5 cell, both fragmented. Those 2 have probably arrested. We finished the consent paperwork and our own bloodtests for the PGS stuff. We'll see how it goes tomorrow. If there are 1 or 2 that look great, we'll transfer them on day 5. If everyone's looking like they'll blast on day 6, we'll biopsy and freeze everything. Stand by to stand by....

Day 4: May 3, 2014: So, OK today. I found out they cultured them separately, so we know who has done what.
2 of the 8 cell-ers from yesterday are fully compacted morulas today. (This is just where they should be.)
2 of the 8 cell-ers from yesterday are 12 cell-ers today with no fragmentation. That's ok. I've had them at 12 cell before and they've made it to blast by day 6.
2 of them are 10 cell-ers. One of them was the 5 cell from yesterday! I'm surprised he turned it around! He has a little fragmentation, but otherwise looks good. What a fighter! The other 10 cell-er was an 8 cell from yesterday.
There's an 8 cell and a 6 cell from yesterday that are an 8 cell and a 6 cell today. That's a bad sign. Too bad about them. I had high hopes for them. :(
The last one is the four cell that was a four cell yesterday and probably a 4 cell the day before. This one's basically out of the running.

So, the plan is to see if 1 or 2 of the morulas are good looking blasts tomorrow and look ready to transfer. If so, we'll transfer at 9 am. If not we'll do no transfer this cycle. We'll just hope as many make it blast as possible and we can biopsy and freeze them.

Day 5: Here we are! So the 2 morulas from yesterday formed a perfect AA hatching blast and a 2cc blast. (We'll talk about the 2cc in a second.) One of the 12 cell-ers from yesterday jumped ahead and made a beautiful AA early blast.

Those 3 were transferred this morning.

The others are now 2 compacted morulas and 2 half compacted morulas. The 2 half compacted morulas don't look that good, so we'll see how they look tomorrow. One of them is the 5 cell to 10 cell from yesterday and the day before. :( Come on little fighter!

So about that 2cc....... They didn't want to transfer it. I insisted. When I looked at it with the embryologist she said that the ICM was actually really well formed, but the trophectoderm was degenerating. So would that make it a 2ac? I looked at some studies and feel really good about the decision to transfer it.

So, without further ado.  Here are the pictures I have: 

The one on the bottom left is the "2CC".  The top one is the top one below and the bottom right one is the bottom one below. 

This is the top one in the picture above.  It was an early blast rated AA in the morning, but really started to expand and by transfer it looks like it's hatching at the one o'clock in the above picture. 

This one is the 2AA in the morning.  It is definitely hatching at transfer which you can see in the top 2 pictures at between the 6 and 7 o'clock.  See that little bit sticking out?  That's the beginning of hatching. 

Day 6:  The embryologist called and stated none had made it to freeze.  Very angry about this.  She said they had made it to blast, but were 2CC and therefore not good enough to freeze.  I don't know if this speaks to an excellent quality for the 2 good ones and for an excellent quality of our frosties or what.  Hindsight being 20/20, I would have transferred the 2 morulas and the runt from above and vitrified and tested the 2 excellent ones with our frozen 7.  I think that would've given the most number of embryos a chance.  Or, I wish I had thought of really forcing the issue to freeze the bad ones.  If they don't survive the thaw, then so be it. At least they would've had a chance....  :(

Oh well, there's many things I would've done differently in this TTC #3 journey.  (Especially started sooner!)  But, all we can do is move forward and do the best we can. 

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